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Disclosures Ildiko Lingvay has performed consultancy for AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Intarcia Therapeutics, Janssen Pharmaceuticals, Inc., MannKind Corporation, Novo Nordisk A/S, Sanofi, TARGET PharmaSolutions and Valeritas, Inc

This is another reason why higher concentrations (10-20mg/mL) are preferred for higher doses, and why the reconstitution charts emphasize these concentrations for the escalation and maintenance phases

Not all the news was good the study also found an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, nephrolithiasis, interstitial nephritis, and drug-induced pancreatitis

"We have to weigh the risks and the benefits, and there are risks here because oftentimes you're dosing these medications at home," said Ellerin.