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1416 Beyond compositional shifts, the functional consequences of dysbiosis are particularly relevant: the microbiota contributes to obesity pathophysiology by driving the production of short-chain fatty acids (SCFAs), modulating bile acid metabolism, and influencing immune and inflammatory pathways

Among the differentially expressed genes, 58 modules were identified as closely associated with microglial GLP-1R pathways and features of nerve injury, including pain hypersensitivity, ligation, paw withdrawal latency, and anxiety-related behaviors [64]