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You should contact your GP or healthcare provider if you experience: Persistent green stools lasting more than a week without obvious dietary explanation Black, tarry stools (melaena), which may indicate upper gastrointestinal bleeding Bright red blood in stools (haematochezia) or on toilet paper Pale, clay-coloured, or white stools , which could suggest bile duct obstruction or liver problems Diarrhoea lasting more than 48 hours , particularly if accompanied by dehydration symptoms Severe abdominal pain , especially if localised to the upper abdomen and radiating to the back, which could indicate pancreatitis (a rare but serious side effect of GLP-1 receptor agonists) Right upper quadrant pain , particularly after fatty meals, which may suggest gallbladder problems Yellowing of the skin or eyes (jaundice) with dark urine, which could indicate liver or gallbladder issues Signs of dehydration: excessive thirst, dark urine, dizziness, reduced urination, or dry mouth Persistent vomiting preventing adequate fluid or medication intake Unexplained weight loss beyond expected therapeutic effects Fever accompanying stool changes , suggesting possible infection For urgent but non-emergency concerns, contact NHS 111

In the PIONEER program, oral semaglutide was administered in the morning in a fasted state, with up to half a glass of water (120 mL [~ 4 oz]), and waiting 30 min or longer before consuming food, drink, or other oral medications

Sold under the brand name Mounjaro, the drug alone accounted for 1,300 crore in MAT sales, while semaglutide contributed 649 crore

It also acts on vagal afferent neurons that signal the brain on the gut nutrient status