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This tiered approach allows PlexusDx patients to reach optimal therapeutic benefit without overwhelming side effects

In humans, LPS infusion raises GLP-1 levels in healthy young subjects (9)

In patients with mCRPC whose disease progressed during or after treatment with docetaxel, cabazitaxel was shown to improve survival compared with mitoxantrone in a randomized trial (NCT00417079).[65] In this trial, 755 such men were treated with prednisone (10 mg PO qd) and randomly assigned to receive either cabazitaxel (25 mg/m2 IV) or mitoxantrone (12 mg/m2 IV) every 3 weeks.[65][Level of evidence A1] Median OS was 15.1 months in the cabazitaxel arm and 12.7 months in the mitoxantrone study arm (HR death, 0.70

This finding was consistent with the fact that ghrelin preadministration reduced GLP-1-induced Fos expression in the NTS when administered at a 30-min interval but not at a 60-min interval