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Tirzepatide (MD: 10 kg, 95%CI: 12, 8.2), semaglutide (MD: 3.8 kg, 95%CI: 4.9, 2.7), EBID (MD: 2.8 kg, 95%CI: 4.2, 1.4), liraglutide (MD: 2.1 kg, 95%CI: 3.2, 1.1), lixisenatide (MD: 2.0 kg, 95%CI: 3.3, 0.75) and dulaglutide (MD: 1.2 kg, 95%CI: 2.1, 0.25) showed statistically significant reduction in weight from baseline in comparison to traditional antidiabetic drugs (S8 Fig)

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Intervention studies have shown that weight reduction in PwO through caloric restriction alone or in combination with low-impact aerobic exercise results in increased levels of BTMs and decreased BMD values [29, 30]

6 , 264 (2015) Jazayeri, A