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Reusing needles increases the risk of infection, irritation, and reduced drug effectiveness

The only one RCT comparing Tirzepatide with GLP-1RA (SURPASS 2) showed that a significant percentage UACR reduction was achieved only with tirzepatide 15 mg [MD -28.70% (-51.54, -5.86), P = 0.01] but not with 5 and 10 mg doses[31]

Zydus Lifesciences has priced its versions at about 2,200 a month, while Natco Pharma has entered with vial-based semaglutide starting 1,290 monthly, intensifying price competition in the segment.

Some individuals may notice improvements in appetite control and energy levels within the first few weeks of treatment, while significant weight loss typically occurs over several months of consistent use