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Note: animal studies indicate that high doses of DPP-4 inhibitors & GLP-1 agonists cause expansion of cells of the pancreatic ductal glands and can cause premalignant pancreatic intraepithelial lesions (PanIN) that have the potential to progress to pancreatic adenocarcinoma

Cagrilintide monotherapy weight loss In the phase 2 trial over 26 weeks, cagrilintide weight loss ranged from 6.0% to 10.8% of body weight depending on dose

Some patients discovered that specific dietary changes made a substantial difference