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Consequently, GLP-1 that is secreted by intestinal L-cells is rapidly degraded by dipeptylpeptidase-4 (DPP-4) in the endothelium of the portal circulation and in the liver, as well as by a soluble circulating moiety of DPP-4

reduced side effects with similar efficacy and similar blood-delivery levels as compared to injected tirzepatide by the end of the Study