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All of them matter for metabolic health

Decara J, Arrabal S, Beiroa D, Rivera P, Vargas A, Serrano A et al (2016) Antiobesity efficacy of GLP-1 receptor agonist liraglutide is associated with peripheral tissue-specific modulation of lipid metabolic regulators

In addition to its effects on insulin, GIP plays a crucial role in fat accumulation by promoting the activity of adipocyte-expressed lipoprotein lipase and promoting bone formation by preventing osteoclast apoptosis, as evidenced by the thinner bone trabeculae seen in mice lacking GIP receptors [2022]

This user started their Wegovy weight loss journey at 244 lbs (110.7 kg) after previously reaching a high of 318 lbs (144.2 kg)