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Third, while GLP-1RAs are well studied in type 2 diabetes, data for primary prevention in non-diabetic but high-risk individuals remain sparse, including patients with prior ischaemic stroke or transient ischaemic attack and those with high vascular risk driven by obesity, metabolic syndrome, or chronic kidney disease

During this ramp-up period, your brain's satiety centers become increasingly responsive to the GLP-1 signal, meaning you'll naturally eat smaller portions without intense hunger

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Patients with diabetes should seek urgent medical care if they experience persistent blood glucose levels above 300 mg/dL, positive ketones in urine or blood, or symptoms of diabetic ketoacidosis (nausea, vomiting, abdominal pain) after missing doses due to medication damage