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Some patients view these medications as temporary tools to jumpstart weight loss, while others accept them as long-term management for a chronic condition

In the Phase 2 obesity trial, retatrutide 12 mg produced approximately 24.2% mean weight loss at 48 weeks ( Jastreboff et al., NEJM 2023 ), and the Phase 2 type 2 diabetes trial showed strong HbA1c and weight reductions ( Rosenstock et al., Lancet 2023 )

J Clin Endocrinol Metab 2007;92:491-6.ArticlePubMed 43

Combination Approaches : The most effective long-term strategies will likely involve coordinated combinations of medications, behavioral support, and lifestyle modifications tailored to individual needs