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Prior serious hypersensitivity to a GLP-1 medication
Oxidation Dissolved oxygen in the reconstitution water can oxidize sensitive amino acid residues in the tirzepatide chain, particularly methionine and cysteine residues if present
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Kidney Int 97:202212 Gutzwiller J-P, Tschopp S, Bock A, Zehnder CE, Huber AR, Kreyenbuehl M et al (2004) Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men
