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The 2015 American Association of Clinical Endocrinologists (AACE) and American College of Endocrinology (ACE) clinical practice guidelines also note the importance of weight management in patients with type 2 diabetes and recommend the use of antihyperglycemic agents that are associated with weight loss or at least have a neutral effect on body weight (23)

CIBER de Fisiopatologa de la Obesidad y Nutricin is an initiative of ISCIII

Statistical analysis Statistical tests are indicated in figure legends with sample sizes

In addition, the insulin resistance that strengthens A depositions and tau protein hyperphosphorylation can cause microvascular injury and white matter injury in the brain