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The disadvantage is precision at lower doses

Risk 5: Loss of Appetite Regulation Poor absorption = unstable appetite control and inconsistent metabolic response

They are permitted under federal law when an FDA-approved product cannot meet the patient's clinical needs, or when the FDA designates a shortage

After a 36-week induction with maximal doses (10 or 15 mg), participants averaged about 20.9 percent body weight loss, then those switched to placebo regained roughly 14 percent of that week 36 body weight over the following 52 weeks, while continuers lost another 5.5 percent, leaving a final average loss of 25.3 percent for continuers versus 9.9 percent for the switch group