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Description
In summary, GLP-1 (and possibly GIP/GLP-1) receptor agonists could improve asthma outcomes through weight reduction, decreased airway inflammation and mucus secretion, decreased type 2 inflammation signaling, reduction in IL-4, 5, 13, and 33 secretion, reduced mast cell activity, as well as increases in surfactant production and smooth muscle relaxation [57]
Int Immunopharmacol 77:105969 Gaspari T, Liu H, Welungoda I, Hu Y, Widdop RE, Knudsen LB, Simpson RW, Dear AE (2011) A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model
Tirzepatide was designed as a single molecule capable of activating both receptors, with preferential affinity for GIP receptors and moderate affinity for GLP-1 receptors
Epac2-dependent Rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1
