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IMPACT ON SELF-INJECTION DEVICE DESIGN The development of pens for self-injection, which are essentially cartridge-based variable dosing, multi-dosing syringes, coincided with the development of peptide hormones and their frequent daily injections, namely insulin, human growth hormone (hGH), follicle-stimulating hormone (FSH) and parathyroid hormone (PTH), and their use for the administering GLP-1s followed