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A 2025 randomized, double-blind, placebo-controlled trial published in Clinical Nutrition found that 15 mg/day of hydroxytyrosol improved antioxidant and anti-inflammatory status in overweight individuals with prediabetes over 16 weeks, while preserving insulin sensitivity (Moratilla-Rivera et al., 2025)
low long-term adherence with subsequent weight regain
The participants of the study were divided into placebo and exenatide groups (10 mcg twice daily for 18 weeks, with an initial dose of 5 mcg twice daily)
