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Because of their complementary modes of action, basal insulin and GLP-1RAs together act in most of the defects seen in T2DM, in accordance with its complex physiopathology (Fig

Notably, S1R interaction is most pronounced with fluvoxamine and, to a lesser extent, with fluoxetine and escitalopram, conferring immunomodulatory and anti-inflammatory effects, supporting the potential repurposing of this receptor in inflammatory and viral illnesses [13,36-38]

The disadvantage is typically higher overall costs compared to online-only telehealth platforms