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Methods A pooled post hoc analysis of 11 randomized clinical trials (N = 4595) of 1030 weeks duration from the exenatide once-weekly (QW) development program evaluated heart rate with exenatide QW (intervention group) and exenatide twice daily (BID), liraglutide, and non-GLP-1RAs (insulin, metformin, pioglitazone, and sitagliptin) (comparison groups)

Overeating on semaglutide can trigger nausea, vomiting, and gastrointestinal discomfort because the medication slows stomach emptying and reduces hunger signals

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Results vary based on individual metabolism, lifestyle factors, and genetic predispositions that PlexusDx can identify through precision testing