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NICE recommend tirzepatide and semaglutide for patients with at least one weight-related comorbidity and a BMI 35 kg/m 2 (or BMI 30 kg/m 2 and who meet the criteria for referral to specialist weight management services, for semaglutide only) and liraglutide for patients with a BMI 35 kg/m 2 , non-diabetic hyperglycaemia, and a high risk of cardiovascular disease

Currently, there are 9 GLP-1RAs approved by the FDA, widely used for the treatment of type 2 diabetes

CagriSema is the next in a series of gut hormone analogs with the potential to herald a new era in treating obesity and preventing diabesity

[DOI] [PMC free article] [PubMed] 345.Ma, X