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Obesity and overweight, which are common in patients with DM2, are a factors that favor the development/progression of CKD through both direct and indirect effects.69 Although the precise mechanisms the association between obesity and CKD are not totally defined it has been proposed that hypertension, glomerular hyperfiltration, hyperglycemia, lipid toxicity, inflammation or the role of adipose tissue and its adipokines are involved.70 Weight reduction by bariatric surgery, pharmacological treatment or dietary measures are associated with a nephroprotective effect,7173 so that weight reduction is a fundamental objective in the nephroprotection of patients with DKD

Both approaches require a valid prescription, but they differ in how you interact with your doctor

Consumers using GLP-1 agonists are navigating a complex journey balancing their diet, managing diabetes, focusing on weight loss, and dealing with side effects of this effort like nausea, digestive discomfort, or altered taste

Indeed, there is evidence that truncated GLP-1 (9-36amide) has no effect on glucose clearance or insulin secretion in healthy humans [196]