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Furthermore, in a 12-week trial, semaglutide was shown to reduce body weight predominantly through appetite suppression, but this effect was also accompanied by a marked reduction in preference for high-fat foods (Blundell et al., 2017)

Both MASH and MASLD are marked by excessive fat in the liver, which can be dangerous

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Discontinuation rates due to adverse events were higher in the active treatment groups compared with placebo, particularly at higher doses, though the overall discontinuation rate remained relatively modest