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These findings align with what researchers observe when studying GLP-1 and GIP agonist side effect profiles

Likewise, among adults with overweight or obesity who completed a 20-week run-in period with subcutaneous semaglutide, 2.4 mg once weekly, maintaining treatment with semaglutide resulted in reduction of mean body weight of 7.9 %, while switching to placebo resulted in increased body weight of 6.9 % over the following 48 weeks [172]

The highest risk appears to be in patients with type 2 diabetes who have established diabetic retinopathy at the time of treatment initiation, particularly when aggressive glycemic targets are pursued rapidly without appropriate ophthalmologic monitoring