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Doctors may prescribe it for high cholesterol if it helps address an obesity-related medical condition, though that is currently considered off-label use

In the SURPASS 1-5 trials, different dosages of Tirzepatide (5 mg, 10 mg, and 15 mg) demonstrated significant weight reduction in obese patients with type 2 diabetes mellitus (T2DM), especially when compared to placebo (SURPASS 1) (25), semaglutide 1 mg (SURPASS 2) (26), insulin degludec (SURPASS 3) (27), insulin glargine (SURPASS 4) (28), and placebo+ insulin glargine (SURPASS 5) (29)

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58: 975 983 [DOI] [PMC free article] [PubMed] [Google Scholar] 8.Buteau J