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There are several proposed hypotheses for how this occurs: Inside-out hypothesis: an endothelial-intimal disruption or flap develops first and then blood enters the sub-intimal space from the true lumen via this flap Outside-in hypothesis: a hematoma forms within the media, possibly from disruption of traversing micro-vessels, and compresses and occludes the true lumen as the hematoma expands

While these advancements are encouraging signs that progress is being made when it comes to treating obesity through medications, it is important that they still be administered only under medical supervision given their associated risks