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Efficacy Estimand Change from Baseline HbA1c, source: Additionally, the 12 mg and 36 mg doses demonstrated clinically meaningful and statistically significant reductions in body weight compared to the placebo
However, some GI side effects still occur and the adherence requirement (empty stomach, etc.) requires patient education

Samuels MH, Kolobova I, Smeraglio A, Peters D, Purnell JQ, Schuff KG

(3) study of responses to carbohydrates and non-carbohydrate challenges in insulin-based care of hyperinsulinism and T2D (ref
