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Description
Since GLP-1 antagonists slow digestion, they may worsen certain gastrointestinal conditions

For context, participants in the STEP 1 clinical trial taking 2.4 mg of semaglutide lost an average of 14.9% of their body weight over 68 weeks

Anyone studying peptide formulation understands that longer amino acid chains create stability challenges

The next frontier of GLP-1s was reached with the launch of Novo Nordisks oral GLP-1 pill, which was approved at the tail end of 2025 and became widely available in early January
