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Before initiating JANUVIA, ask patients about a history of heart failure or other risk factors for heart failure including moderate to severe renal impairment

Increased beta-cell function and insulin biosynthesis has been demonstrated for both liraglutide and semaglutide, with favorable proinsulin/insulin ratios compared with other glucose-lowering agents (124, 141, 143, 152155)

Saxenda, Wegovy, and Mounjaro are meant to be injected into the fatty layer just under your skin, whereas a patch is applied to your skin like a plaster

The Action Plan: Week by Week If you've been on Reta for 4-6 weeks with no results, here's a concrete plan: Week 1: Assess and track Take photos and measurements (waist, hips, chest) Log all food intake honestly for 7 days Note subjective effects (appetite, energy, sleep, GI symptoms) Week 2: Adjust dose if needed If no side effects and no satiety changes, titrate up by 0.5-1mg If GI symptoms are present, hold current dose Week 3-4: Optimize protein and training Hit protein target daily (track it) Ensure resistance training 3-4x/week Increase water to 3+ liters Week 5-6: Reassess Compare photos and measurements to week 1 If still no movement, consider diet break or vendor change If body composition is improving (even without scale change), stay the course Frequently Asked Questions Q: Should I increase my dose faster if nothing is happening