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14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below

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doi: 10.1371/journal.pone.0094112 3 VancampfortDFirthJCorrellCUSolmiMSiskindDDe HertMet al

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