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By the time you reach higher doses, you exceed the capacity of a standard 1mL insulin syringe
If you experience unusual side effects from a vial that is approaching or past its BUD, consider that the medication condition, not the medication itself, might be the cause

Satiety associated with calorie restriction and time-restricted feeding: peripheral hormones
Reductions of those dimensions were also observed in the non-fasting state, except for high-fat cravings