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A very good example is linagliptin, which is predominantly excreted through the bile rather than through the kidneys
Related studies have shown that regulating the biological abundance of the GM can modulate the onset and progression of diseases, and thus the GM is a potential new target that may offer new therapeutic options for the treatment of metabolic diseases (Tanabe et al., 2019)
Moreover, in mice, genetic deletion of GLP-1 receptors enhances ApoB-48 secretion in the absence of changes in gastric emptying (76)
doi:10.1016/S2213-8587(20)30038-3 25
