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( 2 (PLA 2 ) to mitigate the production of lyso-PC which is a critical step in binding pCRP and bringing it into juxtaposition to the apolar membrane zone (83)

[DOI] [PubMed] [Google Scholar] 6.Newman DJ, Cragg GM

The potential for the therapeutic use of CETP inhibitors in humans was first suggested when it was discovered in 1985 that a small population of Japanese had an inborn error in the CETP gene leading to hyperalphalipoproteinemia and very high HDL levels

As for mammalian TRPCs, which are most closely related to the Drosophila channel, Drosophila TRP is absolutely dependent upon PLC activity