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Moreover, clinical observational studies have indicated that MSC-based treatments fail to significantly improve pregnancy outcomes in some patients with severe IUA, suggesting that cell viability and bioactivity are still limited by individual variation

14 Moreover, exosomes derived from LPS-preconditioned bone marrow MSCs have been demonstrated to accelerate wound healing by transferring TSG-6 to modulate the NF-B/NLRP3 signaling pathway, resulting in the switch of macrophages to an M2-like subtype

doi: 10.1136/jnnp.2007.131045

The most common type of cutaneous porphyriaand the most commonis porphyria cutanea tarda, which affects about 5 to 10 out of every 100,000 people