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In a patient that is burdened with cytokine storm, the best thing for the immune system would be to supply it with reduced glutathione such that it is already able to supply reducing equivalents from its thiol group

For example, a study of MTHFR polymorphism genotypes in colorectal cancer patients reported that the frequency of methylated Bcl-2 promoter was significantly higher in individuals with CC genotype than that of those with CT and TT genotypes, and a significant difference of C and T alleles distribution were observed between patients with methylated and unmethylated Bcl-2 promoter 35

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