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The rupture of cell membranes within the tissue results in the combination of polyphenol substrates with polyphenol peroxidases, initiating browning reactions

238,239,240 ERK, JNK, and p38 MAPK are three primary MAPK signaling pathways that may activate transcription factors such as AP-1 and NF-B to release pro-inflammatory cytokines like TNF-, IL-1, and NO

These adhesion molecules are crucial for the migration of immune cells across the blood artery wall, and their overexpression during reperfusion adds to tissue inflammation and the possibility for multi-organ failure (Anzai et al., 2022)

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