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A study showed that ROS signals are transduced mainly by the oxidative stress transcriptional factors SKN-1 (Nrf2 or NFE2L2 in mammals) and JUN-1, and partially by DAF-16

While it may not cross the blood-brain barrier as aggressively as ALCAR, its ability to simultaneously deliver fatty acids and a direct Krebs cycle intermediate makes it unparalleled for supporting sustained cardiovascular energy, systemic endurance, and mitochondrial ATP production

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