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Overall, published studies have demonstrated that the virulence of this fungus is multifactorial, associated with its structure, its capacity for growth and adaptation to stress conditions, its mechanisms for evading the immune system and its ability to cause damage to the host

The zygosity of the T-DNA inserts in the cyp203 SALK line were confirmed to be homozygous by polymerase chain reaction (PCR) using gene-specific primers and a left border primer complementary to the T-DNA insert ( Supplementary Table 1 )

Discussion Here we used a combination of molecular modelling, biochemistry, in vitro and in vivo experiments to specifically target FOXO4 in the FOXO4-TP53 interaction and show induction of apoptosis of senescent cancer cells