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In addition, reduced glutathione deficiency in regulatory T cells (Treg) leads to abnormal serine metabolism and down-regulates transcription factor forkhead box P3 (Foxp3), which ultimately attenuates the immunosuppressive function of Treg (56)

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Lipid peroxidation is the process to generate lipid hydroperoxides (LOOHs) through which intermediate of peroxyl radicals formatted by ROS combines with lipids (ex-PUFA/PL;phospholipid) [32]

Methylation in Methyl B12 sufficiency Methylation is also required for the formation of Melatonin, in which the enzyme Hydroxyindole-O-Methyltransferase using SAMe to methylate NAcetylSerotonin to form Melatonin