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10.1016/j.ccell.2021.05.015 Cancer Cell

non-conservative amino acid substitution refers to the amino acids substitution of an amino acid in one class with an amino acid from another class for example, substitution of an Ala, a class II residue, with a class III residue such as Asp, Asn, Glu, or Gin
Surveillance data from 2014 to 2024 demonstrated a sustained upward trajectory in NAE reports associated with GLP-1 RAs, peaking in 20232024 (Fig

Acknowledgments GH thanks the Prince Sattam Bin Abdulaziz University (Grant No