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Antioxidants can inhibit lipid peroxidation by removing molecular oxygen or by decreasing the local concentration of molecular oxygen, removing pro-oxidative metal ions, trapping aggressive ROS, scavenging chain initiating radicals, breaking the chain of free radical reactions, and quenching singlet oxygen [7,41]

D., Clements P

Experimental screening yielded an impressive 88% binding hit rate, with 50% showing functional activity, including three nanomolar ligands and two novel chemotypes

Seemingly, KYNA (and its 7-chloro derivative) can also be effluxed by MRCP4 (ABCC4) as well as by SLC22A6/8 [242,244], as each of these transporters is inhibited by probenecid, whose presence led to an 885-fold increase in the concentration of 7-Cl-KYNA in the prefrontal cortex of rats [242] (see also [240,245,246,247,248,249,250])