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It is as effective as oral tetracycline, as shown in a double-blind RCT consisting of 46 patients with Hurley stage I and mild stage II HS

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Rajasekaran NS, Connell P, Christians ES, Yan LJ, Taylor RP, Orosz A, Zhang XQ, Stevenson TJ, Peshock RM, Leopold JA, Barry WH, Loscalzo J, Odelberg SJ, Benjamin IJ (2007) Human alphaB-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice

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