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Critical role of ROS and vicious cycles Convincing evidence shows that copper generates ROS, with hydroxyl radicals as the main toxic product
Trends Biochem Sci (2014) 39(4):1918
In the liver, the 25-hydroxylase enzymes (CYP2R1 and CYP27A1) convert inactive cholecalciferol to 25(OH)VD 3 (calcidiol) by carbon 25 hydroxylation 14
N Engl J Med 377(1):6270
