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Description
The hydrolysis rate is influenced by the electron-withdrawing properties of the substituents, with acyl hydrazone cleavable linkers showing a unique balance of stability at neutral pH and lability at acidic pH
Monitoring is equally non-negotiable
One difference between their model and the one reported here is that deletion of Gclc is induced in hepatocytes of adult mice (which are slowly proliferating), compared to theirs, where deletion of Gclc occurred in hepatocytes of growing animals (which are rapidly proliferating)
Eur J Endocrinol 1998
