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We have shown that effective pharmacologic inhibition of GPX4 in PTC cells with direct inhibitor RSL3 induces a robust activation of ferroptosis, increased DNA damage, impaired DNA damage repair response due to reduced p-NPM1 levels, decreased cell viability and cell migration, as well as suppressed spheroid formation and viability in vitro

In addition, greater flavonoid consumption post-diagnosis was associated with a 22% lower risk of mortality

A study conducted in 2011 found that taking a twice-daily 500 mg glutathione supplement did not increase whole blood erythrocyte glutathione or plasma glutathione levels compared to a control group.[8] A separate study from 2019 investigated the impact of 500 mg and 1000 mg of glutathione on glutathione levels in 12 participants

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