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Loop-swapped chimeras of the agouti-related protein and the agouti signaling protein identify contacts required for melanocortin 1 receptor selectivity and antagonism

There are several pathological conditions that cause a decrease in glycolysis and an increase in plasma glucose

Freeze-substitution was carried out in water-free acetone containing 1% OsO 4 for 8 h at 90 C, 7 h at 60 C, 5 h at 30 C, 1 h at 0 C, with transition gradients of 30 C/h, followed by 30 min incubation at RT
