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Notably, astrocyte-specific cholesterol synthesis inhibition significantly alleviates A and Tau pathology in AD mice, indicating glial cholesterol metabolism exerts transcellular regulatory effects (134)

Animal studies involving new monomeric peptides that have agonistic properties at more than a single site have been shown to reduce body weight and improve glycaemia by combining activity at GLP-1, glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptors [12]

In vivo distribution and toxicity of PAMAM dendrimers in the central nervous system depend on their surface chemistry