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However, long-term use of rapamycin may also lead to side effects such as immunosuppression and interference with protein synthesis [288]

These included elevated levels of branched-chain amino acids (BCAA), supporting energy production, and increased formate production, which may aid purine synthesis and cellular resilience

Similarly, Minocycline treatment of monkeys and mice produced more severe and rapid parkinsonism, behavior deficits, and greater loss of nerve endings (Diguet et al., 2004)

Skin concerns such as dullness, pigmentation, fine lines, and uneven tone are often caused by oxidative stress, environmental exposure, and reduced cellular activity