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In guinea pigs fed a high-cholesterol diet, dietary inclusion of moringa leaves (2 or 3.5 g/day) significantly reduced hepatic cholesterol and triglyceride levels, inflammatory cytokines (IL-1, IL-10, IFN-), and histologically evident liver steatosis, without altering plasma lipid profiles

This means that any genetic or nutritional impairment that reduces methionine availability or transsulfuration pathway efficiency reduces the cysteine pool available to GCLC for glutathione synthesis

G3 (Bethesda) 4:16711680

TABLE 13 In vivo studies using Drosophila melanogaster fly
