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The trend for injections was not affected by the pandemic

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Similarly, thiazolidinediones (TZDs), such as pioglitazone and rosiglitazone, exert antioxidant effects by activating peroxisome proliferator-activated receptor gamma (PPAR), reducing systemic and vascular oxidative stress, and attenuating NOX-mediated ROS production, partly through AMPK activation [447,448]

Both disorders involve protein clearance dysfunction: AD is associated with amyloid-beta and tau accumulation, while SCA3 is associated with mutant ataxin-3 aggregates that disrupt autophagy by destabilizing Beclin-1 1,82