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There are also reports that rupture of the respiratory or intestinal epithelial barrier and weakening of other barriers, for example, the bloodbrain barrier or the vascular endothelial barrier, may facilitate the development of metabolic and autoimmune diseases [55, 81,82,83,84]

The National Sleep Foundation recommends that adults should aim for between 7-9 hours for optimum sleep a night, possibly falling to 7-8 hours for the over-65s

10.1513/AnnalsATS.201610-750OC Ann Am Thorac Soc

This type of anemia is often referred to as megaloblastic anemia because the red blood cells that are produced are much larger than normal